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The Laboratory of Thalamus Research is dedicated to study the structural and functional principles of thalamocortical and corticothalamic information transfer, with special emphasis on the role of thalamus in higher order cognitive operations. The majority of thalamus transmits non-sensory information to limbic, associational and motor cortices still information about the nature of this communication is very limited. The major aim of the laboratory is to uncover the synaptic organization and network activity of non-sensory thalamus using the most up-to-date anatomical and physiological methods




All higher order brain operations require continuous interaction between thalamus and neocortex and almost all major neurological and neuropsychiatric diseases result in a disruption of the normal communication between thalamus and cortex. Indeed, all cortical territories are in reciprocal connection with the thalamus and the lesion of any thalamic nuclei causes symptoms similar to that of the cortical area it is connected to. Thalamus and cortex develop together during the ontogenesis and evolve together during the phylogenesis. This indicates that thalamus and cortex form one functional unit and one cannot be understood without the other. 

The scope of thalamus research is presently still very limited and is largely confined to primary sensory functions. However, primary sensory nuclei constitute only the minority of thalamus. The role of the rest (the majority) of the thalamus is only vaguely understood. 



Our research shows that the basic synaptic architecture of thalamic nuclei can be highly variable. As a consequence the principles of information transfer in the thalamus display nucleus specific features.  




Therefore the mission of the Laboratory of Thalamus Research is 

- to understand the generation and function of nucleus specific thalamocortical signals in
normal and diseased states 


- to understand the nature and significance of the perpetual two-way interaction between
thalamus and cortex.


To this end László Acsády’s group utilizes a combined morphological and in vivo electrophysiological approach. The technological repertoire consists of light, electron, confocal, and
superresolution microscopy, immunocytochemistry, virus mediated gene transfer, transgenic technology, juxta- and intracellular recording and labeling, optogenetics and the use of multishank, multisite silicon probes in vivo.



Last Updated on Thursday, 10 September 2015 16:21